December 1 is World AIDS Day, a time to remember the 34 million people in the world today living with HIV. Half a million have died in the US alone. More than two thirds of those living with HIV are in sub-Saharan Africa where I have lived for many years. For every one person with the virus in the blood steam, weakening the immune system, countless others are affected—parents, children, friends, employers, employees, whole communities loosing economic power as wage earners become too ill to work. Anti-retroviral drugs have greatly extended the lives and health of people living with HIV, but the virus still presents huge challenges.